Transcription factors with Perturb-seq knockdown data for ENSG00000286257. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286257 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286257, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:56,552,658–56,553,598 | 507.8 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr14:56,579,396–56,580,264 | 481.1 kb | Distal (>10kb) Multiome HiCAR | 723 | |
| chr14:56,659,300–56,659,979 | 401.1 kb | Distal (>10kb) Multiome HiCAR | 126 | |
| chr14:56,797,476–56,799,717 | 261.8 kb | Distal (>10kb) Multiome HiCAR | 305 | |
| chr14:56,804,880–56,806,970 | 254.9 kb | Distal (>10kb) Multiome HiCAR | 343 | |
| chr14:56,846,930–56,847,795 | 213.4 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr14:56,855,868–56,856,570 | 204.6 kb | Distal (>10kb) Multiome HiCAR | 256 | |
| chr14:56,858,307–56,858,852 | 202.1 kb | Distal (>10kb) Multiome HiCAR | 104 | |
| chr14:56,998,512–56,999,273 | 61.9 kb | Distal (>10kb) Multiome | 139 | |
| chr14:57,049,791–57,050,396 | 10.7 kb | Distal (>10kb) Multiome | 43 | |
| chr14:57,057,835–57,058,099 | 2.6 kb | Proximal (<10kb) | 184 | |
| chr14:57,060,261–57,060,970 | at TSS | At TSS | 180 | |
| chr14:57,066,982–57,067,221 | 6.3 kb | Proximal (<10kb) | 178 | |
| chr14:57,068,510–57,068,949 | 7.8 kb | Proximal (<10kb) | 44 | |
| chr14:57,069,822–57,070,031 | 9.1 kb | Proximal (<10kb) | 40 | |
| chr14:57,268,159–57,269,344 | 208.0 kb | Distal (>10kb) Multiome | 916 |
Genomic view of the ENSG00000286257 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.