Transcription factors with Perturb-seq knockdown data for ENSG00000286254. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286254 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286254, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:6,978,618–6,979,848 | 250.1 kb | Distal (>10kb) Multiome | 110 | |
| chr5:7,261,044–7,261,664 | 31.9 kb | Distal (>10kb) Multiome | 173 | |
| chr5:7,268,880–7,270,186 | 40.4 kb | Distal (>10kb) Multiome | 87 | |
| chr5:7,394,056–7,396,946 | 166.7 kb | Distal (>10kb) Multiome | 276 |
Genomic view of the ENSG00000286254 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.