Transcription factors with Perturb-seq knockdown data for ENSG00000286147. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286147 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286147, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:106,519,101–106,519,370 | 6.0 kb | Proximal (<10kb) | 6 | |
| chr4:106,519,481–106,519,804 | 5.6 kb | Proximal (<10kb) | 3 | |
| chr4:106,525,238–106,525,762 | at TSS | At TSS | 22 | |
| chr4:106,532,983–106,533,626 | 7.6 kb | Proximal (<10kb) | 3 |
Genomic view of the ENSG00000286147 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.