Transcription factors with Perturb-seq knockdown data for ENSG00000286138. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286138 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286138, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,680,480–7,681,546 | 263.2 kb | Distal (>10kb) Multiome | 679 | |
| chr19:7,829,238–7,830,666 | 114.1 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 90.5 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 81.2 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 75.1 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 71.8 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 69.4 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 55.5 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 40.3 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 26.0 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 23.3 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 17.7 kb | Distal (>10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 130 bp | At TSS Multiome | 974 | |
| chr19:8,001,954–8,002,874 | 58.5 kb | Distal (>10kb) Multiome | 475 | |
| chr19:8,005,202–8,006,197 | 61.8 kb | Distal (>10kb) Multiome | 729 | |
| chr19:8,050,174–8,051,154 | 106.8 kb | Distal (>10kb) Multiome | 467 | |
| chr19:8,148,316–8,149,986 | 205.6 kb | Distal (>10kb) Multiome | 381 | |
| chr19:8,203,277–8,204,384 | 259.9 kb | Distal (>10kb) Multiome | 150 | |
| chr19:8,208,086–8,210,178 | 265.3 kb | Distal (>10kb) Multiome | 712 |
Genomic view of the ENSG00000286138 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.