Transcription factors with Perturb-seq knockdown data for ENSG00000286069. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286069 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286069, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,440,979–53,441,838 | 298.0 kb | Distal (>10kb) Multiome | 779 | |
| chr12:53,451,563–53,453,067 | 287.6 kb | Distal (>10kb) Multiome | 999 | |
| chr12:53,492,147–53,494,149 | 246.5 kb | Distal (>10kb) Multiome | 702 | |
| chr12:53,498,714–53,500,111 | 240.2 kb | Distal (>10kb) Multiome | 454 | |
| chr12:53,500,242–53,501,839 | 238.6 kb | Distal (>10kb) Multiome | 1010 | |
| chr12:53,625,664–53,626,787 | 113.4 kb | Distal (>10kb) Multiome | 880 | |
| chr12:53,675,553–53,677,839 | 63.5 kb | Distal (>10kb) Multiome | 1104 | |
| chr12:53,696,162–53,696,648 | 43.1 kb | Distal (>10kb) Multiome | 228 | |
| chr12:53,727,002–53,728,055 | 12.0 kb | Distal (>10kb) Multiome | 768 | |
| chr12:53,738,393–53,738,964 | 847 bp | At TSS Multiome | 131 | |
| chr12:53,743,493–53,743,898 | 6.9 kb | Proximal (<10kb) | 192 | |
| chr12:53,746,454–53,746,954 | 7.2 kb | Proximal (<10kb) Multiome | 503 | |
| chr12:53,756,873–53,757,721 | 17.7 kb | Distal (>10kb) Multiome | 367 | |
| chr12:53,938,348–53,939,947 | 199.0 kb | Distal (>10kb) Multiome | 537 | |
| chr12:53,984,667–53,985,381 | 245.4 kb | Distal (>10kb) Multiome | 456 | |
| chr12:54,017,619–54,018,921 | 278.4 kb | Distal (>10kb) Multiome | 663 |
Genomic view of the ENSG00000286069 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.