Transcription factors with Perturb-seq knockdown data for ENSG00000286044. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286044 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286044, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:121,451,709–121,452,820 | 222.0 kb | Distal (>10kb) Multiome | 653 | |
| chr11:121,479,068–121,480,080 | 194.7 kb | Distal (>10kb) Multiome | 154 | |
| chr11:121,655,309–121,656,263 | 18.4 kb | Distal (>10kb) Multiome | 722 | |
| chr11:121,722,316–121,723,780 | 48.7 kb | Distal (>10kb) Multiome | 681 | |
| chr11:121,800,724–121,801,415 | 126.8 kb | Distal (>10kb) Multiome | 84 | |
| chr11:122,215,191–122,215,725 | 541.3 kb | Distal (>10kb) Multiome HiCAR | 274 |
Genomic view of the ENSG00000286044 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.