Transcription factors with Perturb-seq knockdown data for ENSG00000285763. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285763 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285763, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,403,471–10,405,165 | 255.1 kb | Distal (>10kb) Multiome | 843 | |
| chr6:10,411,106–10,413,568 | 246.8 kb | Distal (>10kb) Multiome | 571 | |
| chr6:10,414,758–10,415,892 | 244.2 kb | Distal (>10kb) Multiome | 461 | |
| chr6:10,416,662–10,418,068 | 242.3 kb | Distal (>10kb) Multiome | 274 | |
| chr6:10,418,929–10,420,110 | 240.0 kb | Distal (>10kb) Multiome | 403 | |
| chr6:10,487,538–10,488,562 | 171.6 kb | Distal (>10kb) Multiome | 115 | |
| chr6:10,520,974–10,521,572 | 138.2 kb | Distal (>10kb) Multiome | 516 | |
| chr6:10,555,376–10,556,448 | 103.6 kb | Distal (>10kb) Multiome | 264 | |
| chr6:10,582,607–10,584,703 | 76.5 kb | Distal (>10kb) Multiome | 306 | |
| chr6:10,585,189–10,585,988 | 73.8 kb | Distal (>10kb) Multiome | 131 | |
| chr6:10,659,291–10,660,431 | 366 bp | At TSS Multiome | 202 | |
| chr6:10,694,307–10,695,190 | 35.2 kb | Distal (>10kb) Multiome | 980 | |
| chr6:10,722,577–10,723,508 | 63.5 kb | Distal (>10kb) Multiome | 960 | |
| chr6:10,747,079–10,748,260 | 88.2 kb | Distal (>10kb) Multiome | 1006 | |
| chr6:10,837,383–10,838,947 | 179.0 kb | Distal (>10kb) Multiome | 773 | |
| chr6:10,882,510–10,883,313 | 223.5 kb | Distal (>10kb) Multiome | 144 | |
| chr6:10,886,419–10,887,541 | 227.5 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the ENSG00000285763 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.