Transcription factors with Perturb-seq knockdown data for ENSG00000285728. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285728 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285728, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:42,455,770–42,457,060 | 225.7 kb | Distal (>10kb) Multiome | 881 | |
| chr1:42,462,753–42,463,783 | 219.0 kb | Distal (>10kb) Multiome | 581 | |
| chr1:42,657,991–42,659,026 | 23.8 kb | Distal (>10kb) Multiome | 952 | |
| chr1:42,681,723–42,683,347 | 135 bp | At TSS Multiome | 924 | |
| chr1:42,739,796–42,740,734 | 58.1 kb | Distal (>10kb) Multiome | 365 | |
| chr1:42,765,982–42,767,804 | 85.0 kb | Distal (>10kb) Multiome | 899 | |
| chr1:42,816,354–42,817,722 | 135.0 kb | Distal (>10kb) Multiome | 721 | |
| chr1:42,845,973–42,847,060 | 164.3 kb | Distal (>10kb) Multiome | 723 | |
| chr1:42,923,882–42,925,144 | 242.3 kb | Distal (>10kb) Multiome | 878 | |
| chr1:42,957,739–42,959,536 | 276.8 kb | Distal (>10kb) Multiome | 943 |
Genomic view of the ENSG00000285728 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.