Transcription factors with Perturb-seq knockdown data for ENSG00000285679. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285679 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285679, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:7,147,232–7,148,825 | 780.3 kb | Distal (>10kb) Multiome HiCAR | 609 | |
| chrX:7,925,940–7,926,157 | 2.3 kb | Proximal (<10kb) | 99 | |
| chrX:7,926,973–7,927,985 | 978 bp | At TSS Multiome | 662 | |
| chrX:7,934,945–7,935,282 | 6.5 kb | Proximal (<10kb) | 17 |
Genomic view of the ENSG00000285679 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.