Transcription factors with Perturb-seq knockdown data for ENSG00000285454. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285454 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285454, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:41,866,914–41,867,668 | 283.6 kb | Distal (>10kb) Multiome | 127 | |
| chr4:41,934,796–41,935,930 | 215.8 kb | Distal (>10kb) Multiome | 814 | |
| chr4:41,989,790–41,991,167 | 160.5 kb | Distal (>10kb) Multiome | 816 | |
| chr4:42,150,652–42,153,392 | 1.4 kb | Proximal (<10kb) Multiome | 429 | |
| chr4:42,293,904–42,294,951 | 143.5 kb | Distal (>10kb) Multiome | 138 | |
| chr4:42,396,619–42,400,207 | 246.5 kb | Distal (>10kb) Multiome | 519 |
Genomic view of the ENSG00000285454 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.