Transcription factors with Perturb-seq knockdown data for ENSG00000285205. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285205 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285205, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:94,486,142–94,486,886 | 283.7 kb | Distal (>10kb) Multiome | 437 | |
| chr14:94,689,361–94,690,123 | 80.6 kb | Distal (>10kb) Multiome | 366 | |
| chr14:94,762,880–94,765,691 | 6.6 kb | Proximal (<10kb) Multiome | 156 | |
| chr14:94,769,514–94,771,036 | 50 bp | At TSS Multiome | 463 | |
| chr14:94,771,191–94,771,577 | 921 bp | At TSS | 62 | |
| chr14:94,771,685–94,772,421 | 1.4 kb | Proximal (<10kb) | 38 | |
| chr14:94,772,857–94,773,397 | 2.6 kb | Proximal (<10kb) | 72 | |
| chr14:94,773,854–94,774,248 | 3.6 kb | Proximal (<10kb) | 56 | |
| chr14:94,774,975–94,776,127 | 5.3 kb | Proximal (<10kb) Multiome | 178 | |
| chr14:94,776,794–94,777,527 | 6.9 kb | Proximal (<10kb) Multiome | 56 | |
| chr14:94,780,572–94,781,427 | 10.8 kb | Distal (>10kb) Multiome | 92 | |
| chr14:94,795,994–94,796,839 | 26.1 kb | Distal (>10kb) Multiome | 94 | |
| chr14:94,893,323–94,894,201 | 123.4 kb | Distal (>10kb) Multiome | 189 |
Genomic view of the ENSG00000285205 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.