Transcription factors with Perturb-seq knockdown data for ENSG00000284959. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284959 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284959, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:80,941,041–80,942,411 | 228.6 kb | Distal (>10kb) Multiome | 702 | |
| chr14:80,954,799–80,956,015 | 215.4 kb | Distal (>10kb) Multiome | 534 | |
| chr14:81,163,999–81,164,817 | 5.6 kb | Proximal (<10kb) | 324 | |
| chr14:81,169,725–81,171,107 | 96 bp | At TSS Multiome | 780 | |
| chr14:81,219,039–81,221,949 | 50.7 kb | Distal (>10kb) Multiome | 1204 | |
| chr14:81,323,510–81,324,729 | 153.8 kb | Distal (>10kb) Multiome | 380 | |
| chr14:81,385,875–81,386,791 | 216.0 kb | Distal (>10kb) Multiome | 212 | |
| chr14:81,435,308–81,437,022 | 266.1 kb | Distal (>10kb) Multiome | 802 |
Genomic view of the ENSG00000284959 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.