Transcription factors with Perturb-seq knockdown data for ENSG00000284691. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284691 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284691, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:150,340,210–150,341,978 | 63.7 kb | Distal (>10kb) Multiome HiCAR | 416 | |
| chr7:150,368,010–150,369,898 | 35.9 kb | Distal (>10kb) Multiome HiCAR | 1082 | |
| chr7:150,378,105–150,380,206 | 26.2 kb | Distal (>10kb) Multiome | 966 | |
| chr7:150,383,391–150,384,626 | 21.5 kb | Distal (>10kb) Multiome | 537 | |
| chr7:150,401,607–150,402,937 | 3.2 kb | Proximal (<10kb) Multiome | 307 | |
| chr7:150,404,616–150,406,417 | 23 bp | At TSS Multiome | 952 | |
| chr7:150,977,414–150,979,693 | 573.8 kb | Distal (>10kb) Multiome HiCAR | 629 |
Genomic view of the ENSG00000284691 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.