Transcription factors with Perturb-seq knockdown data for ENSG00000284630. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284630 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284630, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:21,650,780–21,651,192 | 6.6 kb | Proximal (<10kb) | 111 | |
| chr22:21,651,622–21,652,445 | 5.4 kb | Proximal (<10kb) | 719 | |
| chr22:21,657,073–21,658,429 | at TSS | At TSS | 802 | |
| chr22:21,665,721–21,666,577 | 7.9 kb | Proximal (<10kb) | 893 |
Genomic view of the ENSG00000284630 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.