Transcription factors with Perturb-seq knockdown data for ENSG00000283696. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283696 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283696, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:161,117,504–161,118,419 | 281.3 kb | Distal (>10kb) Multiome | 794 | |
| chr1:161,131,760–161,133,351 | 266.7 kb | Distal (>10kb) Multiome | 956 | |
| chr1:161,153,700–161,154,461 | 245.4 kb | Distal (>10kb) Multiome | 816 | |
| chr1:161,158,928–161,160,167 | 239.9 kb | Distal (>10kb) Multiome | 706 | |
| chr1:161,165,740–161,167,170 | 233.1 kb | Distal (>10kb) Multiome | 888 | |
| chr1:161,176,874–161,177,972 | 221.9 kb | Distal (>10kb) Multiome | 910 | |
| chr1:161,201,572–161,202,783 | 197.1 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr1:161,225,326–161,226,910 | 173.5 kb | Distal (>10kb) Multiome | 710 | |
| chr1:161,258,515–161,259,098 | 140.6 kb | Distal (>10kb) Multiome | 281 | |
| chr1:161,305,737–161,306,708 | 93.1 kb | Distal (>10kb) Multiome | 430 | |
| chr1:161,313,977–161,314,703 | 85.1 kb | Distal (>10kb) Multiome | 824 | |
| chr1:161,389,675–161,390,784 | 9.3 kb | Proximal (<10kb) Multiome | 866 | |
| chr1:161,399,098–161,400,259 | 248 bp | At TSS Multiome | 1040 | |
| chr1:161,400,363–161,400,538 | 955 bp | At TSS | 156 | |
| chr1:161,523,599–161,524,629 | 124.7 kb | Distal (>10kb) Multiome | 513 | |
| chr1:161,530,606–161,531,531 | 131.5 kb | Distal (>10kb) Multiome | 645 | |
| chr1:161,539,909–161,540,503 | 140.8 kb | Distal (>10kb) Multiome | 653 | |
| chr1:161,612,174–161,612,901 | 213.1 kb | Distal (>10kb) Multiome | 601 |
Genomic view of the ENSG00000283696 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.