Transcription factors with Perturb-seq knockdown data for ENSG00000282440. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000282440 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000282440, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:156,319,450–156,320,925 | at TSS | At TSS | 436 | |
| chr2:156,321,600–156,321,854 | 1.3 kb | Proximal (<10kb) | 72 | |
| chr2:156,322,585–156,323,203 | 2.3 kb | Proximal (<10kb) | 89 | |
| chr2:156,325,499–156,326,202 | 5.2 kb | Proximal (<10kb) | 58 | |
| chr2:156,327,528–156,328,450 | 7.3 kb | Proximal (<10kb) | 107 | |
| chr2:156,328,946–156,330,425 | 8.7 kb | Proximal (<10kb) | 234 |
Genomic view of the ENSG00000282440 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.