Transcription factors with Perturb-seq knockdown data for ENSG00000280511. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000280511 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000280511, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:76,480,728–76,481,755 | 80.0 kb | Distal (>10kb) Multiome | 247 | |
| chr6:76,555,169–76,555,441 | 5.9 kb | Proximal (<10kb) | 73 | |
| chr6:76,557,784–76,558,719 | 2.6 kb | Proximal (<10kb) | 25 | |
| chr6:76,560,933–76,561,770 | 70 bp | At TSS Multiome | 232 | |
| chr6:76,562,266–76,562,729 | 939 bp | At TSS | 62 | |
| chr6:76,802,686–76,803,769 | 241.9 kb | Distal (>10kb) Multiome | 148 |
Genomic view of the ENSG00000280511 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.