Transcription factors with Perturb-seq knockdown data for ENSG00000280383. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000280383 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000280383, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:45,413,403–45,414,177 | 243.3 kb | Distal (>10kb) Multiome | 453 | |
| chr22:45,435,549–45,435,992 | 221.2 kb | Distal (>10kb) Multiome | 461 | |
| chr22:45,443,959–45,444,454 | 212.8 kb | Distal (>10kb) Multiome | 24 | |
| chr22:45,502,050–45,504,452 | 154.3 kb | Distal (>10kb) Multiome | 701 | |
| chr22:45,629,603–45,630,068 | 27.1 kb | Distal (>10kb) Multiome | 249 | |
| chr22:45,645,487–45,646,063 | 11.2 kb | Distal (>10kb) Multiome | 469 | |
| chr22:45,671,242–45,672,505 | 14.8 kb | Distal (>10kb) Multiome | 734 | |
| chr22:45,849,833–45,850,431 | 193.1 kb | Distal (>10kb) Multiome | 19 | |
| chr22:45,978,612–45,979,356 | 322.0 kb | Distal (>10kb) Multiome HiCAR | 567 |
Genomic view of the ENSG00000280383 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.