Transcription factors with Perturb-seq knockdown data for ENSG00000280161. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000280161 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000280161, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:180,802,126–180,804,080 | 6.3 kb | Proximal (<10kb) | 796 | |
| chr5:180,804,100–180,804,921 | 5.5 kb | Proximal (<10kb) | 215 | |
| chr5:180,805,012–180,805,347 | 5.1 kb | Proximal (<10kb) | 108 | |
| chr5:180,808,516–180,808,935 | 1.5 kb | Proximal (<10kb) | 204 | |
| chr5:180,809,580–180,811,300 | at TSS | At TSS | 1018 |
Genomic view of the ENSG00000280161 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.