Transcription factors with Perturb-seq knockdown data for ENSG00000279692. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279692 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279692, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,386,455–81,387,640 | 9.5 kb | Proximal (<10kb) | 603 | |
| chr17:81,393,141–81,395,575 | 1.6 kb | Proximal (<10kb) | 1168 | |
| chr17:81,396,480–81,397,832 | at TSS | At TSS | 646 | |
| chr17:81,398,227–81,398,784 | 1.1 kb | Proximal (<10kb) | 281 | |
| chr17:81,399,276–81,400,125 | 2.1 kb | Proximal (<10kb) | 337 | |
| chr17:81,400,287–81,400,955 | 3.1 kb | Proximal (<10kb) | 392 | |
| chr17:81,401,986–81,402,170 | 4.8 kb | Proximal (<10kb) | 290 |
Genomic view of the ENSG00000279692 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.