Transcription factors with Perturb-seq knockdown data for ENSG00000279659. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279659 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279659, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:79,568,949–79,569,872 | 4.0 kb | Proximal (<10kb) | 38 | |
| chr6:79,570,263–79,571,258 | 2.6 kb | Proximal (<10kb) | 384 | |
| chr6:79,574,295–79,574,445 | 418 bp | At TSS | 18 | |
| chr6:79,574,749–79,575,148 | 872 bp | At TSS | 162 |
Genomic view of the ENSG00000279659 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.