Transcription factors with Perturb-seq knockdown data for ENSG00000279641. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279641 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279641, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,233,847–7,235,210 | 7.0 kb | Proximal (<10kb) | 1020 | |
| chr17:7,237,531–7,238,757 | 3.4 kb | Proximal (<10kb) | 502 | |
| chr17:7,238,867–7,240,155 | 2.0 kb | Proximal (<10kb) | 783 | |
| chr17:7,241,494–7,243,462 | at TSS | At TSS | 1037 | |
| chr17:7,251,263–7,252,962 | 9.1 kb | Proximal (<10kb) | 985 |
Genomic view of the ENSG00000279641 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.