Transcription factors with Perturb-seq knockdown data for ENSG00000279446. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279446 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279446, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:127,072,928–127,073,820 | at TSS | At TSS | 757 | |
| chr5:127,073,990–127,075,174 | 404 bp | At TSS | 75 | |
| chr5:127,075,317–127,075,483 | 1.7 kb | Proximal (<10kb) | 12 | |
| chr5:127,077,445–127,077,835 | 3.9 kb | Proximal (<10kb) | 96 | |
| chr5:127,079,734–127,081,090 | 6.1 kb | Proximal (<10kb) | 341 |
Genomic view of the ENSG00000279446 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.