Transcription factors with Perturb-seq knockdown data for ENSG00000279342. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279342 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279342, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:124,622,373–124,623,302 | 170.0 kb | Distal (>10kb) Multiome | 828 | |
| chr11:124,673,250–124,674,391 | 119.0 kb | Distal (>10kb) Multiome | 715 | |
| chr11:124,739,482–124,740,822 | 52.9 kb | Distal (>10kb) Multiome | 498 | |
| chr11:124,745,504–124,747,699 | 45.8 kb | Distal (>10kb) Multiome | 676 | |
| chr11:124,758,225–124,760,203 | 34.3 kb | Distal (>10kb) Multiome | 594 | |
| chr11:124,793,797–124,793,950 | 979 bp | At TSS | 118 | |
| chr11:124,799,320–124,800,957 | 7.7 kb | Proximal (<10kb) Multiome | 893 | |
| chr11:124,839,093–124,840,110 | 46.9 kb | Distal (>10kb) Multiome | 246 | |
| chr11:124,875,886–124,877,815 | 83.7 kb | Distal (>10kb) Multiome | 769 | |
| chr11:124,920,725–124,921,671 | 128.4 kb | Distal (>10kb) Multiome | 329 | |
| chr11:124,953,809–124,954,493 | 161.3 kb | Distal (>10kb) Multiome | 818 | |
| chr11:125,062,600–125,064,019 | 270.4 kb | Distal (>10kb) Multiome | 640 |
Genomic view of the ENSG00000279342 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.