Transcription factors with Perturb-seq knockdown data for ENSG00000279045. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279045 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279045, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:89,548,782–89,548,938 | at TSS | At TSS | 7 | |
| chr11:89,553,044–89,553,422 | 4.2 kb | Proximal (<10kb) | 3 | |
| chr11:89,553,871–89,554,068 | 5.1 kb | Proximal (<10kb) | 51 | |
| chr11:89,556,356–89,556,571 | 7.6 kb | Proximal (<10kb) | 2 | |
| chr11:89,557,345–89,557,927 | 8.6 kb | Proximal (<10kb) | 93 |
Genomic view of the ENSG00000279045 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.