Transcription factors with Perturb-seq knockdown data for ENSG00000277542. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000277542 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000277542, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,718,468–48,719,563 | 4.1 kb | Proximal (<10kb) | 164 | |
| chr17:48,719,708–48,720,337 | 3.4 kb | Proximal (<10kb) | 181 | |
| chr17:48,722,219–48,723,762 | at TSS | At TSS | 220 | |
| chr17:48,724,560–48,724,774 | 869 bp | At TSS | 101 | |
| chr17:48,728,286–48,729,570 | 4.6 kb | Proximal (<10kb) | 376 | |
| chr17:48,732,776–48,733,593 | 9.1 kb | Proximal (<10kb) | 298 |
Genomic view of the ENSG00000277542 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.