Transcription factors with Perturb-seq knockdown data for ENSG00000276668. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000276668 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000276668, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:7,507,737–7,508,506 | 192.0 kb | Distal (>10kb) Multiome | 150 | |
| chr11:7,512,733–7,514,729 | 186.2 kb | Distal (>10kb) Multiome | 725 | |
| chr11:7,571,498–7,572,368 | 128.1 kb | Distal (>10kb) Multiome | 461 | |
| chr11:7,573,550–7,574,414 | 126.1 kb | Distal (>10kb) Multiome | 486 | |
| chr11:7,672,897–7,674,787 | 26.4 kb | Distal (>10kb) Multiome | 379 | |
| chr11:7,694,695–7,694,985 | 5.0 kb | Proximal (<10kb) | 174 | |
| chr11:7,905,555–7,906,470 | 206.1 kb | Distal (>10kb) Multiome | 98 | |
| chr11:7,909,636–7,910,173 | 209.8 kb | Distal (>10kb) Multiome | 37 | |
| chr11:7,986,569–7,987,645 | 287.2 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the ENSG00000276668 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.