Transcription factors with Perturb-seq knockdown data for ENSG00000276517. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000276517 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000276517, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:32,277,550–32,278,517 | 248.5 kb | Distal (>10kb) Multiome | 913 | |
| chr2:32,356,410–32,358,403 | 169.5 kb | Distal (>10kb) Multiome | 1140 | |
| chr2:32,381,392–32,382,477 | 144.8 kb | Distal (>10kb) Multiome | 98 | |
| chr2:32,627,287–32,628,586 | 101.5 kb | Distal (>10kb) Multiome | 825 |
Genomic view of the ENSG00000276517 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.