Transcription factors with Perturb-seq knockdown data for ENSG00000275764. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000275764 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000275764, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:26,831,973–26,834,292 | 203.7 kb | Distal (>10kb) Multiome | 945 | |
| chr12:26,884,786–26,885,430 | 152.1 kb | Distal (>10kb) Multiome | 412 | |
| chr12:26,937,248–26,939,182 | 98.8 kb | Distal (>10kb) Multiome | 853 | |
| chr12:27,013,686–27,014,988 | 22.7 kb | Distal (>10kb) Multiome | 864 | |
| chr12:27,021,899–27,022,924 | 14.6 kb | Distal (>10kb) Multiome | 783 | |
| chr12:27,243,875–27,245,004 | 207.1 kb | Distal (>10kb) Multiome | 897 | |
| chr12:27,332,152–27,333,788 | 295.9 kb | Distal (>10kb) Multiome | 640 |
Genomic view of the ENSG00000275764 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.