Transcription factors with Perturb-seq knockdown data for ENSG00000275481. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000275481 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000275481, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:46,267,263–46,270,142 | 119.6 kb | Distal (>10kb) Multiome | 1114 | |
| chr12:46,370,990–46,374,187 | 16.0 kb | Distal (>10kb) Multiome | 1163 | |
| chr12:46,382,727–46,384,328 | 5.4 kb | Proximal (<10kb) Multiome | 1071 | |
| chr12:46,387,008–46,387,180 | 1.7 kb | Proximal (<10kb) | 231 | |
| chr12:46,392,688–46,392,943 | 3.8 kb | Proximal (<10kb) | 217 |
Genomic view of the ENSG00000275481 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.