Transcription factors with Perturb-seq knockdown data for ENSG00000274964. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000274964 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000274964, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,659,057–31,659,786 | 680.1 kb | Distal (>10kb) Multiome HiCAR | 737 | |
| chr12:32,106,218–32,107,295 | 232.6 kb | Distal (>10kb) Multiome | 874 | |
| chr12:32,139,428–32,140,190 | 199.4 kb | Distal (>10kb) Multiome | 274 | |
| chr12:32,398,922–32,400,774 | 60.2 kb | Distal (>10kb) Multiome | 832 | |
| chr12:32,501,832–32,502,447 | 162.7 kb | Distal (>10kb) Multiome | 347 | |
| chr12:32,678,963–32,680,020 | 339.9 kb | Distal (>10kb) Multiome HiCAR | 960 |
Genomic view of the ENSG00000274964 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.