Transcription factors with Perturb-seq knockdown data for ENSG00000274272. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000274272 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000274272, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,569,177–100,570,642 | 8.1 kb | Proximal (<10kb) | 855 | |
| chr7:100,571,007–100,573,075 | 5.6 kb | Proximal (<10kb) | 388 | |
| chr7:100,573,670–100,574,027 | 4.7 kb | Proximal (<10kb) | 170 | |
| chr7:100,584,803–100,585,060 | 6.1 kb | Proximal (<10kb) | 236 | |
| chr7:100,585,161–100,587,241 | 6.5 kb | Proximal (<10kb) | 966 |
Genomic view of the ENSG00000274272 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.