Transcription factors with Perturb-seq knockdown data for ENSG00000273759. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273759 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273759, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,921,311–62,921,558 | 7.7 kb | Proximal (<10kb) | 359 | |
| chr20:62,925,950–62,926,856 | 2.4 kb | Proximal (<10kb) | 874 | |
| chr20:62,926,946–62,927,259 | 2.0 kb | Proximal (<10kb) | 220 | |
| chr20:62,928,980–62,929,573 | at TSS | At TSS | 289 | |
| chr20:62,937,285–62,938,569 | 8.0 kb | Proximal (<10kb) | 1026 |
Genomic view of the ENSG00000273759 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.