Transcription factors with Perturb-seq knockdown data for ENSG00000273729. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273729 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273729, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:77,024,027–77,024,710 | 3.4 kb | Proximal (<10kb) | 368 | |
| chr14:77,025,547–77,029,182 | at TSS | At TSS | 996 | |
| chr14:77,029,256–77,029,523 | 1.2 kb | Proximal (<10kb) | 251 | |
| chr14:77,032,573–77,034,628 | 4.5 kb | Proximal (<10kb) | 917 |
Genomic view of the ENSG00000273729 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.