Transcription factors with Perturb-seq knockdown data for ENSG00000273284. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273284 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273284, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:9,102,098–9,103,261 | 156.7 kb | Distal (>10kb) Multiome | 815 | |
| chr18:9,135,781–9,137,908 | 122.0 kb | Distal (>10kb) Multiome | 1018 | |
| chr18:9,260,959–9,261,242 | 1.6 kb | Proximal (<10kb) | 28 | |
| chr18:9,264,819–9,265,280 | 5.4 kb | Proximal (<10kb) | 49 | |
| chr18:9,333,728–9,335,352 | 75.2 kb | Distal (>10kb) Multiome | 738 | |
| chr18:9,474,512–9,476,246 | 216.0 kb | Distal (>10kb) Multiome | 971 | |
| chr18:9,495,937–9,496,497 | 236.8 kb | Distal (>10kb) Multiome | 78 |
Genomic view of the ENSG00000273284 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.