Transcription factors with Perturb-seq knockdown data for ENSG00000273156. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273156 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273156, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:82,284,318–82,285,814 | 61.8 kb | Distal (>10kb) Multiome | 566 | |
| chr4:82,346,001–82,346,404 | 437 bp | At TSS | 37 | |
| chr4:82,372,612–82,374,867 | 27.4 kb | Distal (>10kb) Multiome | 1174 | |
| chr4:82,428,720–82,431,310 | 82.5 kb | Distal (>10kb) Multiome | 1120 | |
| chr4:82,561,307–82,562,355 | 215.0 kb | Distal (>10kb) Multiome | 327 |
Genomic view of the ENSG00000273156 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.