Transcription factors with Perturb-seq knockdown data for ENSG00000272884. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272884 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272884, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,435,167–7,437,681 | 1.8 kb | Proximal (<10kb) | 828 | |
| chr17:7,437,892–7,438,555 | 949 bp | At TSS | 224 | |
| chr17:7,440,048–7,441,211 | 543 bp | At TSS | 487 | |
| chr17:7,444,968–7,446,142 | 5.5 kb | Proximal (<10kb) | 632 |
Genomic view of the ENSG00000272884 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.