Transcription factors with Perturb-seq knockdown data for ENSG00000272807. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272807 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272807, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:208,406,386–208,407,453 | 1621.5 kb | Distal (>10kb) Multiome HiCAR | 324 | |
| chr2:209,771,427–209,772,913 | 256.5 kb | Distal (>10kb) Multiome | 849 | |
| chr2:209,817,604–209,818,340 | 210.4 kb | Distal (>10kb) Multiome | 183 | |
| chr2:209,960,058–209,961,333 | 67.5 kb | Distal (>10kb) Multiome | 269 | |
| chr2:210,002,022–210,003,279 | 25.8 kb | Distal (>10kb) Multiome | 811 | |
| chr2:210,034,436–210,034,820 | 6.0 kb | Proximal (<10kb) | 29 | |
| chr2:210,169,996–210,172,503 | 143.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr2:210,181,086–210,182,197 | 153.3 kb | Distal (>10kb) Multiome | 168 | |
| chr2:210,224,566–210,225,799 | 196.7 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the ENSG00000272807 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.