Transcription factors with Perturb-seq knockdown data for ENSG00000272800. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272800 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272800, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:182,929,762–182,930,671 | 248.6 kb | Distal (>10kb) Multiome | 149 | |
| chr2:183,037,288–183,039,108 | 140.3 kb | Distal (>10kb) Multiome | 915 | |
| chr2:183,070,887–183,071,694 | 107.5 kb | Distal (>10kb) Multiome | 230 | |
| chr2:183,078,264–183,079,391 | 100.1 kb | Distal (>10kb) Multiome | 744 | |
| chr2:183,123,970–183,125,139 | 54.3 kb | Distal (>10kb) Multiome | 982 | |
| chr2:183,172,014–183,172,844 | 6.0 kb | Proximal (<10kb) | 78 | |
| chr2:183,185,359–183,185,939 | 6.6 kb | Proximal (<10kb) | 65 | |
| chr2:183,291,337–183,292,555 | 113.4 kb | Distal (>10kb) Multiome | 173 |
Genomic view of the ENSG00000272800 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.