TFs regulating ENSG00000272631 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000272631. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272631 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000272631

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272631, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:86,520,920–86,522,476	234.4 kb	Distal (>10kb) Multiome	901
chr10:86,535,238–86,536,949	220.7 kb	Distal (>10kb) Multiome	617
chr10:86,585,119–86,585,766	170.7 kb	Distal (>10kb) Multiome	421
chr10:86,599,659–86,600,297	156.3 kb	Distal (>10kb) Multiome	111
chr10:86,631,854–86,632,698	124.0 kb	Distal (>10kb) Multiome	226
chr10:86,693,793–86,694,266	62.4 kb	Distal (>10kb) Multiome	132
chr10:86,710,752–86,712,521	45.0 kb	Distal (>10kb) Multiome	898
chr10:86,755,517–86,757,638	199 bp	At TSS Multiome	902
chr10:86,864,876–86,866,168	109.0 kb	Distal (>10kb) Multiome	123
chr10:86,939,081–86,939,963	183.3 kb	Distal (>10kb) Multiome	539
chr10:86,953,950–86,955,264	198.2 kb	Distal (>10kb) Multiome	348
chr10:86,959,879–86,960,855	204.3 kb	Distal (>10kb) Multiome	453
chr10:86,966,444–86,967,440	210.6 kb	Distal (>10kb) Multiome	479
chr10:86,969,969–86,972,224	215.1 kb	Distal (>10kb) Multiome	505

Genome Browser

Genomic view of the ENSG00000272631 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.