Transcription factors with Perturb-seq knockdown data for ENSG00000272540. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272540 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272540, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,716,986–30,717,874 | 6.0 kb | Proximal (<10kb) | 1059 | |
| chr6:30,719,428–30,720,577 | 3.3 kb | Proximal (<10kb) | 724 | |
| chr6:30,720,820–30,721,086 | 2.8 kb | Proximal (<10kb) | 500 | |
| chr6:30,721,307–30,722,103 | 1.8 kb | Proximal (<10kb) | 872 | |
| chr6:30,722,280–30,722,892 | 984 bp | At TSS | 533 | |
| chr6:30,725,731–30,726,564 | 1.9 kb | Proximal (<10kb) | 478 | |
| chr6:30,730,722–30,731,175 | 6.8 kb | Proximal (<10kb) | 476 |
Genomic view of the ENSG00000272540 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.