Transcription factors with Perturb-seq knockdown data for ENSG00000272328. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272328 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272328, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:7,099,297–7,099,939 | 1204.0 kb | Distal (>10kb) Multiome HiCAR | 535 | |
| chr7:7,640,013–7,641,632 | 663.1 kb | Distal (>10kb) Multiome HiCAR | 966 | |
| chr7:8,261,188–8,262,737 | 41.5 kb | Distal (>10kb) Multiome | 655 | |
| chr7:8,295,941–8,296,411 | 7.3 kb | Proximal (<10kb) | 258 | |
| chr7:8,303,841–8,304,163 | 100 bp | At TSS | 117 | |
| chr7:8,389,706–8,390,552 | 86.3 kb | Distal (>10kb) Multiome | 193 | |
| chr7:8,433,115–8,435,899 | 130.3 kb | Distal (>10kb) Multiome | 645 | |
| chr7:8,441,662–8,444,713 | 139.2 kb | Distal (>10kb) Multiome | 474 |
Genomic view of the ENSG00000272328 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.