Transcription factors with Perturb-seq knockdown data for ENSG00000271533. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271533 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271533, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:73,943,883–73,944,593 | 269.4 kb | Distal (>10kb) Multiome | 973 | |
| chrX:74,249,927–74,250,404 | 36.5 kb | Distal (>10kb) Multiome | 183 | |
| chrX:74,259,954–74,260,568 | 46.5 kb | Distal (>10kb) Multiome | 106 | |
| chrX:74,292,249–74,293,905 | 78.9 kb | Distal (>10kb) Multiome | 594 | |
| chrX:74,325,234–74,326,322 | 112.0 kb | Distal (>10kb) Multiome | 229 | |
| chrX:74,419,854–74,421,997 | 206.8 kb | Distal (>10kb) Multiome | 370 | |
| chrX:74,422,455–74,423,310 | 209.3 kb | Distal (>10kb) Multiome | 202 |
Genomic view of the ENSG00000271533 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.