Transcription factors with Perturb-seq knockdown data for ENSG00000271253. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271253 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271253, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:12,681,715–12,682,210 | 3.4 kb | Proximal (<10kb) | 15 | |
| chr7:12,683,777–12,683,944 | 1.7 kb | Proximal (<10kb) | 57 | |
| chr7:12,684,789–12,684,943 | 692 bp | At TSS | 17 | |
| chr7:12,685,524–12,686,068 | at TSS | At TSS | 136 | |
| chr7:12,686,188–12,688,064 | 552 bp | At TSS | 1066 |
Genomic view of the ENSG00000271253 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.