Transcription factors with Perturb-seq knockdown data for ENSG00000271155. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271155 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271155, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:95,504,550–95,504,792 | 1.4 kb | Proximal (<10kb) | 150 | |
| chr9:95,505,799–95,509,826 | at TSS | At TSS | 860 | |
| chr9:95,510,553–95,511,685 | 4.3 kb | Proximal (<10kb) | 774 | |
| chr9:95,512,046–95,512,812 | 5.8 kb | Proximal (<10kb) | 301 | |
| chr9:95,515,877–95,516,112 | 9.6 kb | Proximal (<10kb) | 241 |
Genomic view of the ENSG00000271155 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.