Transcription factors with Perturb-seq knockdown data for ENSG00000270571. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000270571 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000270571, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,919,661–74,920,281 | 234.3 kb | Distal (>10kb) Multiome | 376 | |
| chr2:74,958,221–74,959,258 | 195.6 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:75,055,603–75,056,664 | 98.0 kb | Distal (>10kb) Multiome | 263 | |
| chr2:75,153,714–75,154,360 | 120 bp | At TSS Multiome | 222 | |
| chr2:75,199,295–75,200,926 | 46.3 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the ENSG00000270571 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.