Transcription factors with Perturb-seq knockdown data for ENSG00000270175. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000270175 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000270175, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,492,147–53,494,149 | 7.4 kb | Proximal (<10kb) | 702 | |
| chr12:53,496,158–53,496,570 | 5.0 kb | Proximal (<10kb) | 188 | |
| chr12:53,498,714–53,500,111 | 1.5 kb | Proximal (<10kb) | 454 | |
| chr12:53,500,242–53,501,839 | at TSS | At TSS | 1010 | |
| chr12:53,508,612–53,509,050 | 7.0 kb | Proximal (<10kb) | 366 |
Genomic view of the ENSG00000270175 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.