Transcription factors with Perturb-seq knockdown data for ENSG00000269958. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000269958 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000269958, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,518,427–103,519,043 | 177.6 kb | Distal (>10kb) Multiome | 404 | |
| chr14:103,520,443–103,523,552 | 173.4 kb | Distal (>10kb) Multiome | 756 | |
| chr14:103,528,671–103,529,619 | 167.2 kb | Distal (>10kb) Multiome | 726 | |
| chr14:103,561,982–103,563,356 | 133.6 kb | Distal (>10kb) Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 67.2 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 19.3 kb | Distal (>10kb) Multiome | 709 | |
| chr14:103,846,809–103,848,686 | 151.3 kb | Distal (>10kb) Multiome | 711 | |
| chr14:103,855,145–103,855,758 | 159.1 kb | Distal (>10kb) Multiome | 418 | |
| chr14:103,871,719–103,872,659 | 175.7 kb | Distal (>10kb) Multiome | 313 | |
| chr14:103,910,266–103,910,793 | 214.1 kb | Distal (>10kb) Multiome | 374 | |
| chr14:103,921,195–103,921,889 | 225.2 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the ENSG00000269958 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.