Transcription factors with Perturb-seq knockdown data for ENSG00000269095. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000269095 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000269095, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,244,882–17,247,104 | 8.3 kb | Proximal (<10kb) | 862 | |
| chr19:17,247,935–17,248,860 | 6.6 kb | Proximal (<10kb) | 588 | |
| chr19:17,260,923–17,261,240 | 5.5 kb | Proximal (<10kb) | 503 | |
| chr19:17,264,709–17,264,934 | 9.3 kb | Proximal (<10kb) | 119 |
Genomic view of the ENSG00000269095 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.