Transcription factors with Perturb-seq knockdown data for ENSG00000268750. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000268750 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000268750, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,810,480–57,811,177 | 8.5 kb | Proximal (<10kb) | 180 | |
| chr19:57,814,439–57,815,270 | 4.5 kb | Proximal (<10kb) | 692 | |
| chr19:57,819,268–57,819,991 | at TSS | At TSS | 734 | |
| chr19:57,823,783–57,824,252 | 4.1 kb | Proximal (<10kb) | 46 | |
| chr19:57,829,187–57,830,712 | 9.5 kb | Proximal (<10kb) | 321 | |
| chr19:57,830,968–57,831,576 | 657 bp | At TSS | 8 |
Genomic view of the ENSG00000268750 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.